Fried was in control throughout, yielding singles in the second and fourth, and a two-out double to Willy Adames in the sixth. Fried, who won his last seven decisions to finish 14-7, struck out nine with no walks.
Milwaukee had two runners in the each of the three final innings but failed to convert.
Atlanta, whose only run in Friday’s 2-1 opening loss came on Joc Pederson’s pinch-hit homer in the eighth, bunched three consecutive hits for two runs in the third inning off Brandon Woodruff.
Jorge Soler doubled with one out and Freddie Freeman followed with an RBI single to right. Ozzie Albies then doubled off the top of the wall in right.
Austin Riley, who had 33 homers during the regular season, put the Braves up 3-0 with a 428-foot solo homer to right-center with one out in the sixth.
The Brewers threatened in the seventh when Luis Urias singled with two outs and Lorenzo Cain walked, but Tyler Matzek relieved and struck out pinch-hitter Tyrone Taylor.
Jace Peterson walked and Kolten Wong singled to open