The Astros will take a 2-0 series lead to Chicago for Game 3, scheduled for Sunday.
Only 10 baseball teams have come back from an 0-2 deficit to win a best-of-five series, most recently the New York Yankees against the Cleveland Indians in the 2017 AL Division Series.
The White Sox, who never led in a 6-1 loss in Game 1 Thursday, scored three runs in the fifth — via RBI singles by Luis Robert and Jose Abreu and a sacrifice fly by Yasmani Grandal — to take a 4-2 lead.
But the Astros wasted no time beginning to come back against the White Sox, who were 85-10 in regular season games in which they held a two-run lead. Chicago starter Lucas Giolito issued a leadoff walk to Jose Altuve and exited after walking Alex Bregman with one out. Garrett Crochet entered and walked Alvarez before giving up a two-run single to Yuri Gurriel.
The top of the order again keyed the go-ahead surge against Aaron Bummer (0-1) in the seventh. Altuve led off with a single against